Description
What Is GHRP-2?
GHRP-2 is a synthetic hexapeptide and member of the growth hormone secretagogue family. Its sequence is D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NHâ‚‚, incorporating D-amino acids that contribute to its resistance to enzymatic degradation and receptor-binding properties.
GHRP-2 has been investigated extensively for its ability to stimulate growth hormone release through activation of the growth hormone secretagogue receptor type 1a (GHS-R1a).
The compound is also known as pralmorelin and has been used in Japan as a diagnostic agent for evaluating growth hormone deficiency.
How GHRP-2 (Growth Hormone-Releasing Peptide 2) Works
GHS-R1a Receptor Activity
GHRP-2 acts as an agonist at the GHS-R1a receptor, a receptor that also responds to the endogenous hormone ghrelin.
Activation of this receptor initiates intracellular signaling pathways associated with growth hormone secretion from somatotroph cells in the anterior pituitary.
Research has also investigated GHRP-2’s interaction with other receptors and its potential effects beyond growth hormone release.
Growth Hormone Research
Clinical and experimental research has examined GHRP-2 for its ability to produce acute increases in growth hormone concentrations.
Its growth-hormone-releasing activity has been studied both independently and in combination with growth hormone-releasing hormone (GHRH) analogues.
Appetite Research
Because GHRP-2 interacts with the ghrelin receptor pathway, research has also examined its effects on appetite and food intake.
Research Areas
GHRP-2 has been investigated in several areas, including:
- Growth hormone secretion
- GHS-R1a receptor activity
- Growth hormone deficiency research
- Ghrelin-related signaling
- Appetite and food intake
- ACTH and cortisol responses
- Prolactin secretion
- Pituitary function
- GHRP/GHRH interactions
- Cytoprotective research
- Cardiovascular and neurological research
Product Specifications
| Product Specification | Details |
|---|---|
| Product Name | GHRP-2 Peptide |
| Alternative Name | Pralmorelin |
| Peptide Class | Growth Hormone Secretagogue |
| Peptide Type | Synthetic Hexapeptide |
| Strength | 5 mg/vial |
| Form | Lyophilized Powder |
| Packaging | 1 Box |
| Vials per Box | 1 Vial |
| Total Quantity | 5 mg |
| Research Category | Peptide Research |
| Primary Research Target | GHS-R1a Receptor |
| Intended Use | Research / Investigational Use Only |
Research Evidence
GHRP-2 has been examined in clinical and experimental studies investigating growth hormone secretion and pituitary function.
Research by Arvat et al. examined GHRP-2 alongside other secretagogues and demonstrated significant growth hormone responses following administration.
Other research has investigated GHRP-2 in growth hormone deficiency, appetite regulation, and its interactions with the ACTH-cortisol and prolactin systems.
The compound’s pharmaceutical development also led to the use of pralmorelin as a diagnostic growth hormone provocative agent in Japan.
GHRP-2 vs Other GHRPs
| Characteristic | GHRP-2 | GHRP-6 | Ipamorelin |
|---|---|---|---|
| GHS-R1a activity | Yes | Yes | Yes |
| GH-release research | Extensive | Extensive | Extensive |
| Appetite effects | Moderate | More pronounced | Lower |
| Cortisol research | Moderate effects | More pronounced | Minimal |
| Prolactin research | Moderate effects | More pronounced | Minimal |
| Research status | Investigational in many jurisdictions | Investigational | Investigational |
Storage & Handling
GHRP-2 is commonly supplied as a lyophilized, freeze-dried peptide powder.
For research handling, storage conditions should follow the manufacturer’s certificate of analysis and stability information. Avoid unnecessary exposure to heat, moisture, light, and repeated temperature fluctuations.
Research-use handling only.
Frequently Asked Questions
What is GHRP-2?
GHRP-2 is a synthetic hexapeptide belonging to the growth hormone secretagogue family. It has been studied for its activity at the GHS-R1a receptor and its effects on growth hormone secretion.
What is another name for GHRP-2?
GHRP-2 is also known as pralmorelin.
What is GHRP-2 used for in research?
Research has investigated GHRP-2 in growth hormone secretion, pituitary function, appetite regulation, ghrelin signaling, and related physiological pathways.
How much GHRP-2 is included?
This product specification is 5 mg per vial, with 1 vial per box.
Is GHRP-2 FDA approved?
GHRP-2 is not FDA-approved for therapeutic use in the United States.
Is GHRP-2 a growth hormone?
No. GHRP-2 is a growth hormone secretagogue. It is a peptide that has been studied for its ability to stimulate endogenous growth hormone release.
Is GHRP-2 suitable for athletes?
GHRP-2 is prohibited under WADA’s prohibited substances framework. Athletes subject to anti-doping rules should consult their governing organization before using or handling the compound.
Disclaimer
GHRP-2 is provided for research and investigational purposes only. This product is not intended to diagnose, treat, cure, or prevent any disease or medical condition. It is not intended for human or veterinary consumption. Research chemicals should only be handled by qualified professionals in appropriate laboratory settings.







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